prikaz prve stranice dokumenta Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds
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Scientific paper - Original scientific paper
Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE, 18 (2024), 1; 1-16. https://doi.org/10.1080/16583655.2024.2331456
Karnaš, Maja; Rastija, Vesna; Vrandečić, Karolina; Ćosić, Jasenka; Kanižai Šarić, Gabriella; Agić, Dejan; subarić, Domagoj; Molnar, M.

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Karnaš, M., Rastija, V., Vrandečić, K., Ćosić, J., Kanižai Šarić, G., Agić, D. ... Molnar, M.. Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds. JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE, 18. (1), 1-16. doi: 10.1080/16583655.2024.2331456

Karnaš, Maja, et al. "Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds." JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE, vol. 18, no. 1, pp. 1-16. https://doi.org/10.1080/16583655.2024.2331456

Karnaš, Maja, Vesna Rastija, Karolina Vrandečić, Jasenka Ćosić, Gabriella Kanižai Šarić, Dejan Agić, Domagoj subarić and M. Molnar. "Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds." JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE 18, no. 1 1-16. https://doi.org/10.1080/16583655.2024.2331456

Karnaš, M., et al. 'Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds', JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE, 18(1), pp. 1-16. doi: 10.1080/16583655.2024.2331456

Karnaš M, Rastija V, Vrandečić K, Ćosić J, Kanižai Šarić G, Agić D, and sur.. Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds. JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE [Internet]. [cited 2024 December 19];18(1):1-16. doi: 10.1080/16583655.2024.2331456

M. Karnaš, et al., "Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds", JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE, vol. 18, no. 1, pp. 1-16. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:151:479195. [Accessed: 19 December 2024]

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Title (english)Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds
AuthorMaja Karnaš
AuthorVesna Rastija
AuthorKarolina Vrandečić
AuthorJasenka Ćosić
AuthorGabriella Kanižai Šarić
AuthorDejan Agić
AuthorDomagoj subarić
AuthorM. Molnar
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Agrobiotechnical Sciences Osijek
(Department of agroecology and Enviroment Protection)
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Agronomy
Agrochemistry
Abstract (english)
Effective plant pathogen control presents an important challenge. Pesticide resistance and associated health and environmental problems demonstrate the need for novel, safe active ingredients for plant protection. Since both coumarins and 1,2,4-triazoles show pesticidal activity, in this study, we evaluated the antimicrobial activity of coumarin-1,2,4-triazole hybrids against plant pathogenic fungi (Fusarium oxysporum, Fusariumculmorum, Macrophominaphaseolina and Sclerotinia sclerotiorum), bacterial plant pathogens (Pseudomonas syringae and Rhodococcus fascians), and beneficial bacteria (Bacillus mycoides and Bradyrhizobium japonicum). Coumarin-1,2,4- triazoles inhibited the growth of S. sclerotiorum and F. oxysporum, while no antibacterial effect on either pathogens or soil-beneficial bacteria was observed. A quantitative structure–activity relationship models for antifungal activities on S. sclerotiorum and F. oxysporum, developed using Dragon descriptors, can explain 79% and 77% of the compounds inhibitory activity, respectively. According to molecular docking, title compounds are potential sterol 14α-demethylase inhibitors, with 7-((5-mercapto-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)methoxy)-4-methyl-2H-chromen- 2-one as the promising candidate for further research in plant protection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - domestic
Publication versionPublished version
Journal titleJOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
Numberingvol. 18, no. 1, pp. 1-16
e-ISSN1658-3655
DOIhttps://doi.org/10.1080/16583655.2024.2331456
URN:NBNurn:nbn:hr:151:479195
Accepted2024-03-13
Document URLhttps://www.tandfonline.com/doi/pdf/10.1080/16583655.2024.2331456?needAccess=true
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-06-06 11:03:15