prikaz prve stranice dokumenta Novel Synthetic Routes to Quaternary Pyridinium Salts and their Antifungal Activity
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Scientific paper - Original scientific paper
Novel Synthetic Routes to Quaternary Pyridinium Salts and their Antifungal Activity
Croatica Chemica Acta, 95 (2022), 1; 31-38. https://doi.org/10.5562/cca3903
Bušić, Valentina; Vrandečić, Karolina; Siber, Tamara; Roca, Sunčica; Tomičić, Vice; Gašo Sokač, Dajana

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Bušić, V., Vrandečić, K., Siber, T., Roca, S., Tomičić, V. & Gašo Sokač, D. (2022). Novel Synthetic Routes to Quaternary Pyridinium Salts and their Antifungal Activity. Croatica Chemica Acta, 95. (1), 31-38. doi: 10.5562/cca3903

Bušić, Valentina, et al. "Novel Synthetic Routes to Quaternary Pyridinium Salts and their Antifungal Activity." Croatica Chemica Acta, vol. 95, no. 1, 2022, pp. 31-38. https://doi.org/10.5562/cca3903

Bušić, Valentina, Karolina Vrandečić, Tamara Siber, Sunčica Roca, Vice Tomičić and Dajana Gašo Sokač. "Novel Synthetic Routes to Quaternary Pyridinium Salts and their Antifungal Activity." Croatica Chemica Acta 95, no. 1 (2022): 31-38. https://doi.org/10.5562/cca3903

Bušić, V., et al. (2022) 'Novel Synthetic Routes to Quaternary Pyridinium Salts and their Antifungal Activity', Croatica Chemica Acta, 95(1), pp. 31-38. doi: 10.5562/cca3903

Bušić V, Vrandečić K, Siber T, Roca S, Tomičić V, Gašo Sokač D. Novel Synthetic Routes to Quaternary Pyridinium Salts and their Antifungal Activity. Croatica Chemica Acta [Internet]. 2022 November 23 [cited 2025 January 21];95(1):31-38. doi: 10.5562/cca3903

V. Bušić, K. Vrandečić, T. Siber, S. Roca, V. Tomičić and D. Gašo Sokač, "Novel Synthetic Routes to Quaternary Pyridinium Salts and their Antifungal Activity", Croatica Chemica Acta, vol. 95, no. 1, pp. 31-38, November 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:151:645461. [Accessed: 21 January 2025]

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Metadata
Title (english)Novel Synthetic Routes to Quaternary Pyridinium Salts and their Antifungal Activity
AuthorValentina Bušić
AuthorKarolina Vrandečić
AuthorTamara Siber
AuthorSunčica Roca
AuthorVice Tomičić
AuthorDajana Gašo Sokač
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Agrobiotechnical Sciences Osijek
(Department of Phytomedicine)
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Agronomy
Phytomedicine
Abstract (english)
Eleven pyridine derivatives were prepared by quaternization reactions by different synthetic routes: conventional, microwave, and ultrasound. Since acetone and other solvents used in conventional quaternization reactions are harmful, attempts were made to replace the organic solvents with more environmentally friendly alternative - deep eutectic solvents. The reactions were carried out using pyridine-3-aldoxime, pyridine-4-aldoxime, isonicotinamide and nicotinamide as nucleophiles and three different dihaloalkanes as electrophiles: diiodopropane, dibromopropane and diiodohexane. The results showed that the microwave method using acetone as solvent was significantly faster and gave higher yields than the conventional method. In contrast, synthesis in the eutectic solvents choline chloride : urea gave significantly lower yields. The structures of the synthesized compounds were confirmed by 1H and 13C NMR spectroscopy, mass spectrometry and elemental analysis. The antifungal activity of all compounds was tested at two different concentrations (10 and 100 µg mL–1) against Botrytis cinerea, Fusarium culmorum, Macrophomina phaseolina and Sclerotinia sclerotiorum in vitro. All tested compounds showed excellent inhibitory activity against the studied phytopathogenic fungal species at a concentration of 100 µg mL–1.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - domestic
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 95, no. 1, pp. 31-38
p-ISSN0011-1643
e-ISSN1334-417X
DOIhttps://doi.org/10.5562/cca3903
URN:NBNurn:nbn:hr:151:645461
Publication2022-11-23
Document URLhttps://hrcak.srce.hr/286193
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-06-27 10:39:19