intensity of B. cinerea infection on the cultivar Cabernet Sauvignon in the Đakovo vineyards and to determine the differences in qualitative and quantitative parameters that occur when applying different forms of protection with regard to infection caused by gray mold. The research was conducted for a period of three years at a Viticulture and winemaking experimental station Faculty of Agrobiotechnical Sciences Osijek. Fungicides that were used were Teldor SC 500 and Switch 62.5 WG, and biofungicides Trichodex WP and Serenade. Ampelotechnical measures include: removal of basal leaves and cotyledons, blowing of clusters and application of Calcium Chloride. The average value of yield per vine in 2015 was 1.18 kg, in 2016 5.32 kg, and in 2017 3.18 kg. The average sugar content in the must ranged from 87.96 °Oe (2016) to 97 °Oe (2017). Total acidity was measured in the range of 5.29 g / L (2015) to the highest measured 11.13 g / L (2016). For the pH level, the average value ranged from 3.18 (2016) to 3.55 (2015). Total polyphenols ranged from 442.42 mg / L (2015) to 848.05 mg / L (2017). The lowest content of total anthocyanins was 127.60 mg / L (2015), and the highest was 328.14 mg / L (2017). In terms of antioxidant activity, the lowest average content of 7.90 mg / 100g (GAE) was determined in 2015. The highest average antioxidant activity was measured in 2017. (28.45 mg / 100g GAE). The highest average value of polymer color was 5.03% (2017), and the highest was 21.28% (2015). The assessment of the disease was coducted according to the EPPO scale (2001). Average presence of the disease in 2015 was 3.96. In 2016 presence of the disease (1.25) was determined in one treatment (conventional protection with botryticides), while in 2017, the presence of the disease was not recorded in all treatments. ANOVA (p <0.01) revealed a statistically significant difference between the treatments a set of ampelotechnical measures and calcium chloride (for 2016 and 2017), while between other treatments there was no significant difference in grape yield or interaction between treatments and year. A statistically significant influence of the year on all examined treatments was determined