The aim of this study was to determine the phytotoxic effect of grape pomace on growth and development of tomato and pepper seedlings. The grape pomace is heterogeneous mixture of seeds, skin, pulp and small part of the stalks that is formed after the process of pressing grapes. The growth of the wine industry increases the problem of disposal of this solid waste, and winemakers and scientists are trying to find an effective method of recycling and disposal of the pomace. In this study, tomato and pepper seeds were sown, and growth and development were monitored until the transplant stage. After the experiment was completed, certain morphological parameters of seedlings were measured: the number of leaves, stem height, fresh mass of stem, leaves and roots, and dry mass of stem, leaves and roots. After statistical analysis of the data, it was determined that the application of grape pomace affects certain parameters of plant growth and development. The 1: 1 treatment had the highest number of leaves, plant height and the highest fresh stem, leaf and root mass in tomatoes compared to control and other treatments. The dry mass of the stem, leaves and roots of the tomato was not affected by the grape pomace treatment. In the case of peppers, treatments with the grape pomace did not increase the number of leaves and the height of the stem. Also, treatments with the application of grape pomace did not affect the increase of fresh and dry mass of stems and leaves of peppers. It can be concluded that treatments with the application of grape pomace have an impact on certain morphological indicators of growth and development, depending on the culture.