The aim of the present paper was to determine the changes of acid-base indicators in the blood of Alpine goats during pregnancy. The research included 21 French Alpine goats during winter feeding season. Goats were divided per 7 in the group according to stage of pregnancy (up to 3 months, from 3 to 4 months, and more than 4 months). Feeding of goats was with a mixture of grains and meadow hay. In the blood of goats concentrations acid-base indicators (blood pH, BE(efc)), blood gases (pCO2, pO2, tCO2) as well as electrolytes: (Na+, K+, Cl–) and bicarbonate were determined. Afterwards, anion gap (AG), SID (strong ion differences) and z-values were estimated. Comparing determined acidbase indicators in the blood of Alpine goats during various stages of pregnancy significant differences were not evident. Acid-base indicators in blood of Alpine goats did not differ compared to reference values, except AG in blood of Alpine goat during < 3 months of pregnancy (7.52 mmol/l) as well as SID during investigation. Determined significant high correlation of acid-base indicators in blood of Alpine goats during pregnancy was expected since there are physiological connections and participation of various indicators in the calculation of some of the indicators obtained. More significantly high correlations were determined in goats during higher pregnancy (>4 month) which can be associated with an increased load of animals because of intensive development of the foetus. Mentioned minor changes of acid-base indicators in the blood of Alpine goats showed a significant resistance on the occurrence metabolic disease.