prikaz prve stranice dokumenta Antifungal Activities of Fluorinated Pyrazole Aldehydes on Phytopathogenic Fungi, and Their Effect on Entomopathogenic Nematodes, and Soil-Beneficial Bacteria
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Scientific paper - Original scientific paper
Antifungal Activities of Fluorinated Pyrazole Aldehydes on Phytopathogenic Fungi, and Their Effect on Entomopathogenic Nematodes, and Soil-Beneficial Bacteria
International Journal o f Molecular Sciences, 24 (2023), 11; 9335. https://doi.org/10.3390/ijms24119335
Rastija, Vesna; Vrandečić, Karolina; Ćosić, Jasenka; Kanižai Šarić, Gabriella; Majić, Ivana; Agić, Dejan; Šubarić, Domagoj; Karnaš, Maja; Bešlo, Drago; Grahmbhatt, H.; Komar, M.

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Rastija, V., Vrandečić, K., Ćosić, J., Kanižai Šarić, G., Majić, I., Agić, D. ... Komar, M. (2023). Antifungal Activities of Fluorinated Pyrazole Aldehydes on Phytopathogenic Fungi, and Their Effect on Entomopathogenic Nematodes, and Soil-Beneficial Bacteria. International Journal o f Molecular Sciences, 24. (11). doi: 10.3390/ijms24119335

Rastija, Vesna, et al. "Antifungal Activities of Fluorinated Pyrazole Aldehydes on Phytopathogenic Fungi, and Their Effect on Entomopathogenic Nematodes, and Soil-Beneficial Bacteria." International Journal o f Molecular Sciences, vol. 24, no. 11, 2023. https://doi.org/10.3390/ijms24119335

Rastija, Vesna, Karolina Vrandečić, Jasenka Ćosić, Gabriella Kanižai Šarić, Ivana Majić, Dejan Agić, Domagoj Šubarić, et al. "Antifungal Activities of Fluorinated Pyrazole Aldehydes on Phytopathogenic Fungi, and Their Effect on Entomopathogenic Nematodes, and Soil-Beneficial Bacteria." International Journal o f Molecular Sciences 24, no. 11 (2023). https://doi.org/10.3390/ijms24119335

Rastija, V., et al. (2023) 'Antifungal Activities of Fluorinated Pyrazole Aldehydes on Phytopathogenic Fungi, and Their Effect on Entomopathogenic Nematodes, and Soil-Beneficial Bacteria', International Journal o f Molecular Sciences, 24(11). doi: 10.3390/ijms24119335

Rastija V, Vrandečić K, Ćosić J, Kanižai Šarić G, Majić I, Agić D, and sur.. Antifungal Activities of Fluorinated Pyrazole Aldehydes on Phytopathogenic Fungi, and Their Effect on Entomopathogenic Nematodes, and Soil-Beneficial Bacteria. International Journal o f Molecular Sciences [Internet]. 2023 May 26 [cited 2024 November 23];24(11). doi: 10.3390/ijms24119335

V. Rastija, et al., "Antifungal Activities of Fluorinated Pyrazole Aldehydes on Phytopathogenic Fungi, and Their Effect on Entomopathogenic Nematodes, and Soil-Beneficial Bacteria", International Journal o f Molecular Sciences, vol. 24, no. 11, May 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:151:314252. [Accessed: 23 November 2024]

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Title (english)Antifungal Activities of Fluorinated Pyrazole Aldehydes on Phytopathogenic Fungi, and Their Effect on Entomopathogenic Nematodes, and Soil-Beneficial Bacteria
AuthorVesna Rastija
AuthorKarolina Vrandečić
AuthorJasenka Ćosić
AuthorGabriella Kanižai Šarić
AuthorIvana Majić
AuthorDejan Agić
AuthorDomagoj Šubarić
AuthorMaja Karnaš
AuthorDrago Bešlo
AuthorH. Grahmbhatt
AuthorM. Komar
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Agrobiotechnical Sciences Osijek
(Department of agroecology and Enviroment Protection)
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Agronomy
Agrochemistry
Abstract (english)
Fluoro-substituted pyrazoles have a wide range of biological activities, such as antibacterial, antiviral, and antifungal activities. The aim of this study was to evaluate the antifungal activities of fluorinated 4,5-dihydro-1H-pyrazole derivatives on four phytopathogenic fungi: Sclerotinia sclerotiorum, Macrophomina phaseolina, Fusarium oxysporum f. sp. lycopersici, and F. culmorum. Moreover, they were tested on two soil beneficial bacteria—Bacillus mycoides and Bradyrhizobium japonicum—as well as two entomopathogenic nematodes (EPNs)—Heterorhabditis bacteriophora and Steinernema feltiae. The molecular docking was performed on the three enzymes responsible for fungal growth, the three plant cell wall-degrading enzymes, and acetylcholinesterase (AChE). The most active compounds against fungi S. sclerotiorum were 2-chlorophenyl derivative (H9) (43.07% of inhibition) and 2,5- dimethoxyphenyl derivative (H7) (42.23% of inhibition), as well as H9 against F. culmorum (46.75% of inhibition). Compounds were shown to be safe for beneficial soil bacteria and nematodes, except for compound H9 on EPN H. bacteriophora (18.75% mortality), which also showed the strongest inhibition against AChE (79.50% of inhibition). The molecular docking study revealed that antifungal activity is possible through the inhibition of proteinase K, and nematicidal activity is possible through the inhibition of AChE. The fluorinated pyrazole aldehydes are promising components of future plant protection products that could be environmentally and toxicologically acceptable.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - domestic
Publication versionPublished version
Journal titleInternational Journal o f Molecular Sciences
Numberingvol. 24, no. 11, 9335
p-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24119335
URN:NBNurn:nbn:hr:151:314252
Publication2023-05-26
Document URLhttps://www.mdpi.com/1422-0067/24/11/9335
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-06-13 14:32:05