prikaz prve stranice dokumenta Effects of Coumarinyl Schiff Bases against Phytopathogenic Fungi, the Soil-Beneficial Bacteria and Entomopathogenic Nematodes: Deeper Insight into the Mechanism of Action
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Scientific paper - Original scientific paper
Effects of Coumarinyl Schiff Bases against Phytopathogenic Fungi, the Soil-Beneficial Bacteria and Entomopathogenic Nematodes: Deeper Insight into the Mechanism of Action
Molecules, 27 (2022), 7; 2196. https://doi.org/10.3390/molecules27072196
Rastija, Vesna; Vrandečić, Karolina; Ćosić, Jasenka; Kanižai Šarić, Gabriella; Majić, Ivana; Agić, Dejan; Šubarić, Domagoj; Karnaš, Maja; Bešlo, Drago; Komar, D.; Molnar, M.

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Rastija, V., Vrandečić, K., Ćosić, J., Kanižai Šarić, G., Majić, I., Agić, D. ... Molnar, M. (2022). Effects of Coumarinyl Schiff Bases against Phytopathogenic Fungi, the Soil-Beneficial Bacteria and Entomopathogenic Nematodes: Deeper Insight into the Mechanism of Action. Molecules, 27. (7). doi: 10.3390/molecules27072196

Rastija, Vesna, et al. "Effects of Coumarinyl Schiff Bases against Phytopathogenic Fungi, the Soil-Beneficial Bacteria and Entomopathogenic Nematodes: Deeper Insight into the Mechanism of Action." Molecules, vol. 27, no. 7, 2022. https://doi.org/10.3390/molecules27072196

Rastija, Vesna, Karolina Vrandečić, Jasenka Ćosić, Gabriella Kanižai Šarić, Ivana Majić, Dejan Agić, Domagoj Šubarić, et al. "Effects of Coumarinyl Schiff Bases against Phytopathogenic Fungi, the Soil-Beneficial Bacteria and Entomopathogenic Nematodes: Deeper Insight into the Mechanism of Action." Molecules 27, no. 7 (2022). https://doi.org/10.3390/molecules27072196

Rastija, V., et al. (2022) 'Effects of Coumarinyl Schiff Bases against Phytopathogenic Fungi, the Soil-Beneficial Bacteria and Entomopathogenic Nematodes: Deeper Insight into the Mechanism of Action', Molecules, 27(7). doi: 10.3390/molecules27072196

Rastija V, Vrandečić K, Ćosić J, Kanižai Šarić G, Majić I, Agić D, and sur.. Effects of Coumarinyl Schiff Bases against Phytopathogenic Fungi, the Soil-Beneficial Bacteria and Entomopathogenic Nematodes: Deeper Insight into the Mechanism of Action. Molecules [Internet]. 2022 March 28 [cited 2024 November 26];27(7). doi: 10.3390/molecules27072196

V. Rastija, et al., "Effects of Coumarinyl Schiff Bases against Phytopathogenic Fungi, the Soil-Beneficial Bacteria and Entomopathogenic Nematodes: Deeper Insight into the Mechanism of Action", Molecules, vol. 27, no. 7, March 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:151:413442. [Accessed: 26 November 2024]

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Title (english)Effects of Coumarinyl Schiff Bases against Phytopathogenic Fungi, the Soil-Beneficial Bacteria and Entomopathogenic Nematodes: Deeper Insight into the Mechanism of Action
AuthorVesna Rastija
AuthorKarolina Vrandečić
AuthorJasenka Ćosić
AuthorGabriella Kanižai Šarić
AuthorIvana Majić
AuthorDejan Agić
AuthorDomagoj Šubarić
AuthorMaja Karnaš
AuthorDrago Bešlo
AuthorD. Komar
AuthorM. Molnar
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Agrobiotechnical Sciences Osijek
(Department of agroecology and Enviroment Protection)
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Agronomy
Agrochemistry
Abstract (english)
Coumarin derivatives have been reported as strong antifungal agents against various phytopathogenic fungi. In this study, inhibitory effects of nine coumarinyl Schiff bases were evaluated against the plant pathogenic fungi (Fusarium oxysporum f. sp. lycopersici, Fusarium culmorum, Macrophomina phaseolina and Sclerotinia sclerotiourum). The compounds were demonstrated to be efficient antifungal agents against Macrophomina phaseolina. The results of molecular docking on the six enzymes related to the antifungal activity suggested that the tested compounds act against plant pathogenic fungi, inhibiting plant cell-wall-degrading enzymes such as endoglucanase I and pectinase. Neither compound exhibited inhibitory effects against two beneficial bacteria (Bacillus mycoides and Bradyrhizobium japonicum) and two entomopathogenic nematodes. However, compound 9 was lethal (46.25%) for nematode Heterorhabditis bacteriophora and showed an inhibitory effect against acetylcholinesterase (AChE) (31.45%), confirming the relationship between these two activities. Calculated toxicity and the pesticide-likeness study showed that compound 9 was the least lipophilic compound with the highest aquatic toxicity. A molecular docking study showed that compounds 9 and 8 bind directly to the active site of AChE. Coumarinyl Schiff bases are promising active components of plant protection products, safe for the environment, human health, and nontarget organisms.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - domestic
Publication versionPublished version
Journal titleMolecules
Numberingvol. 27, no. 7, 2196
p-ISSN1420-3049
DOIhttps://doi.org/10.3390/molecules27072196
URN:NBNurn:nbn:hr:151:413442
Publication2022-03-28
Document URLhttps://www.mdpi.com/1420-3049/27/7/2196
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-06-13 15:12:37