The study was set up on a family estate in Petrijevci (eastern Croatia) during the lettuce vegetation (Lactuca sativa L.) from the 4th of March to the 21st of May, 2019. The influence of irrigation and variety on the yield and quality of lettuce was studied. The study was conducted according to a split - plot scheme in three repetitions. Irrigation treatments were performed in three different irrigation rations: a1 = 5 l/m2, a2 = 10 l/m2, a3 = 15 l/m2. Two varieties of lettuce were involved in the study: crystal (b1) and butterhead lettuce (b2). When the salad reached full maturity, five plants were harvested from each experimential plot (eighteen in total). The effect of the factors on: yield (kg/m2), head mass (kg), head diameter (cm), number of leaves per head, root length (cm), root mass (g) and root diameter (cm) were studied. The irrigation rate added during the lettuce vegetation period was as follows: on irrigation treatment a1 = 20 mm, on irrigation treatment a2 = 40 mm, and on irrigation treatment a3 = 60 mm. Significantly higher yield (p < 0.05) was achieved with the crystal lettuce variety (b1, 3.63 kg/m2), while irrigation had no statistically valid effect. Also, the lettuce variety significantly influenced (p < 0.05) the weight of (b1, 0,38 kg) and the diameter of the lettuce head (b1, 32,96 cm). Regarding the number of lettuce leaves, a significant influence of irrigation (p < 0.05) was observed, which at a3 treatment was 22 leaves, Also, a significant influence (p < 0,05) of the a x b interaction, i.e. irrigation x variety in the crystal lettuce variety (b1). Irrigation treatment had a significant effect on root length (p < 0.05), which was 14.87 cm with a1 irrigation treatment, whereas no statistically significant influence of irrigation or variety was observed with root diameter.