prikaz prve stranice dokumenta Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds
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Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE, 18 (2024), 1; 1-16. https://doi.org/10.1080/16583655.2024.2331456
Karnaš, Maja; Rastija, Vesna; Vrandečić, Karolina; Ćosić, Jasenka; Kanižai Šarić, Gabriella; Agić, Dejan; subarić, Domagoj; Molnar, M.

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Karnaš, M., Rastija, V., Vrandečić, K., Ćosić, J., Kanižai Šarić, G., Agić, D. ... Molnar, M.. Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds. JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE, 18. (1), 1-16. doi: 10.1080/16583655.2024.2331456

Karnaš, Maja, et al. "Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds." JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE, vol. 18, br. 1, str. 1-16. https://doi.org/10.1080/16583655.2024.2331456

Karnaš, Maja, Vesna Rastija, Karolina Vrandečić, Jasenka Ćosić, Gabriella Kanižai Šarić, Dejan Agić, Domagoj subarić i M. Molnar. "Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds." JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE 18, br. 1 1-16. https://doi.org/10.1080/16583655.2024.2331456

Karnaš, M., et al. 'Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds', JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE, 18(1), str. 1-16. doi: 10.1080/16583655.2024.2331456

Karnaš M, Rastija V, Vrandečić K, Ćosić J, Kanižai Šarić G, Agić D, i sur.. Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds. JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE [Internet]. [pristupljeno 08.12.2024.];18(1):1-16. doi: 10.1080/16583655.2024.2331456

M. Karnaš, et al., "Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds", JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE, vol. 18, br. 1, str. 1-16. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:151:479195. [Citirano: 08.12.2024.]

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Podaci o radu
Naslov (engleski)Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds
AutorMaja Karnaš
AutorVesna Rastija
AutorKarolina Vrandečić
AutorJasenka Ćosić
AutorGabriella Kanižai Šarić
AutorDejan Agić
AutorDomagoj subarić
AutorM. Molnar
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Fakultet agrobiotehničkih znanosti Osijek
(Zavod za agroekologiju i zaštitu okoliša)
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Poljoprivreda (agronomija)
Agrokemija
Sažetak (engleski)
Effective plant pathogen control presents an important challenge. Pesticide resistance and associated health and environmental problems demonstrate the need for novel, safe active ingredients for plant protection. Since both coumarins and 1,2,4-triazoles show pesticidal activity, in this study, we evaluated the antimicrobial activity of coumarin-1,2,4-triazole hybrids against plant pathogenic fungi (Fusarium oxysporum, Fusariumculmorum, Macrophominaphaseolina and Sclerotinia sclerotiorum), bacterial plant pathogens (Pseudomonas syringae and Rhodococcus fascians), and beneficial bacteria (Bacillus mycoides and Bradyrhizobium japonicum). Coumarin-1,2,4- triazoles inhibited the growth of S. sclerotiorum and F. oxysporum, while no antibacterial effect on either pathogens or soil-beneficial bacteria was observed. A quantitative structure–activity relationship models for antifungal activities on S. sclerotiorum and F. oxysporum, developed using Dragon descriptors, can explain 79% and 77% of the compounds inhibitory activity, respectively. According to molecular docking, title compounds are potential sterol 14α-demethylase inhibitors, with 7-((5-mercapto-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)methoxy)-4-methyl-2H-chromen- 2-one as the promising candidate for further research in plant protection.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - domaća recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
Brojčani podacivol. 18, br. 1, str. 1-16
e-ISSN1658-3655
DOIhttps://doi.org/10.1080/16583655.2024.2331456
URN:NBNurn:nbn:hr:151:479195
Datum prihvaćanja za tisak2024-03-13
URL dokumentahttps://www.tandfonline.com/doi/pdf/10.1080/16583655.2024.2331456?needAccess=true
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-06-06 11:03:15